USP25 and 28 inhibitor AZ-2

CAS No. 2165322-95-0

USP25 and 28 inhibitor AZ-2 ( USP25/28 inhibitor AZ2 )

Catalog No. M13456 CAS No. 2165322-95-0

USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    USP25 and 28 inhibitor AZ-2
  • Note
    Research use only, not for human use.
  • Brief Description
    USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
  • Description
    USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
  • Synonyms
    USP25/28 inhibitor AZ2
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2165322-95-0
  • Formula Weight
    420.23
  • Molecular Formula
    C17H17BrF3NO3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1=CC(=CC(=C1)OC(F)(F)F)COC2=C(C=C(C=C2)Br)CNCCO
  • Chemical Name
    2-((5-bromo-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.
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